Neuroendocrine Cells in Barrett’s Mucosa and Adenocarcinomas of the Gastroesophageal Junction-Reference-Cited by-同舟云学术

Neuroendocrine Cells in Barrett’s Mucosa and Adenocarcinomas of the Gastroesophageal Junction

Published:2004-04 Issue:2 Volume:12 Page:117-125
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Koppert Linetta B.¹,Wijnhoven Bas P.L.²,Tilanus Hugo W.²,Stijnen Theo³,van Dekken Herman⁴,Dinjens Winand N. M.⁴

Affiliation:

1. Departments of Surgery and Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, The Netherlands, Rotterdam Esophageal Tumor Study Group

2. Department of Surgery, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, The Netherlands, Rotterdam Esophageal Tumor Study Group

3. Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center Rotterdam, The Netherlands, Rotterdam Esophageal Tumor Study Group

4. Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, The Netherlands, Rotterdam Esophageal Tumor Study Group

Abstract

We estimated the prevalence and prognostic significance of neuroendocrine (NE) cells in a series of 208 resection specimens containing gastroesophageal junction (GEJ) adenocarcinomas, with 56 specimens containing Barrett’s mucosa. Immunohistochemically, chromogranin A (CGA) was positive in 49% (102/208) of GEJ adenocarcinomas and in 68% (38/56) of Barrett’s mucosas. CGA in GEJ tumors correlated with pTNM stage. CGA in Barrett correlated with pTNM stage and tumor grade of the adjacent carcinoma. Patients with CGA in Barrett had better survival than patients without CGA in Barrett, with 5-year survival percentages of 56% and 9%, respectively. In multivariate analysis, CGA in Barrett was an independent prognostic factor for survival after surgery. Therefore CGA in Barrett adjacent to GEJ adenocarcinoma might be helpful in the assessment of patient outcome.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/106689690401200204

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