Clear Cell Change in Colonic Polyps

Author:

Eloy Catarina1,Lopes José M.2,Faria Gil3,Moreira Herculano3,Brandão Abílio4,Silva Teresa5,Carneiro Fátima6

Affiliation:

1. Department of Pathology, Hospital de S. João, Institute of Molecular Pathology and Immunology of the University of Porto

2. Department of Pathology, Hospital de S. João, , Institute of Molecular Pathology and Immunology of the University of Porto, Department of Pathology, Medical Faculty of the University of Porto

3. Department of Surgery, Hospital de S. João, Porto

4. Department of Pathology, Hospital de Aveiro, Aveiro

5. Department of Pathology, Hospitais da Universidade de Coimbra, Coimbra; Portugal

6. Department of Pathology, Hospital de S. João, Institute of Molecular Pathology and Immunology of the University of Porto, Department of Pathology, Medical Faculty of the University of Porto

Abstract

In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 adenoma with clear cell dysplastic glands progressed to adenocarcinoma without clear cell change. Clear cell cytoplasmatic vacuoles were negative for glycogen and mucins (MUC 2, MUC 5AC). Ki-67 LI in clear cell adenoma components was lower than in common adenoma components of the same dysplasia grades (while p53 and β-catenin were similarly expressed). Ultrastructural features of clear cell change showed features of lipid-like material. Clear cell change is found in hyperplastic and neoplastic lesions of the colon and is not due to the accumulation of glycogen or mucins. A degenerative nature of clear cell change is suggested by the demonstration of lipid-like material in the vacuoles of clear cells.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

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