Clinicopathologic and DNA Flow Cytometric Analysis of Eighty-three Renal Cell Carcinomas

Abstract

The clinical and anatomopathologic features as well as DNA content of 83 renal cell carcinomas were analyzed. The possible interrelationship and prognostic value of these factors were also considered. The DNA study has been performed by flow cytometry using paraffin-embedded tissues. In each case an internal control with nonneoplastic renal tissue obtained in the same nefrectomy was also done in order to calculate the DNA index. Differences in patient age, nuclear grade, and mitotic activity were related with outcome; however, this relationship was not confirmed by the Cox test. Stage (P = .005), cell type (P = .002), and metastatic disease (P = .001) had independent prognostic values. Renal cell carcinomas with low stage and with low S-phase had better prognosis. Int J Surg Pathol 3(1):1-8, 1995