The Expression and Clinical Significance of TGF-β1 and MMP2 in Human Renal Clear Cell Carcinoma-Reference-Cited by-同舟云学术

The Expression and Clinical Significance of TGF-β1 and MMP2 in Human Renal Clear Cell Carcinoma

Published:2009-02-17 Issue:2 Volume:18 Page:85-93
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Yang Shu-dong¹,Sun Rong-chao²,Mu Hui-jun³,Xu Zhuo-qun⁴,Zhou Zhi-yi²

Affiliation:

1. Department of Pathology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China,

2. Department of Pathology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China

3. Central Laboratory, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China

4. Department of Urology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China

Abstract

The expression and clinical significance of transforming growth factor β1 (TGF-β1) and matrix metalloproteinase-2 (MMP2) in human renal clear cell carcinoma (RCCC) were investigated. The intensity of TGF-β1 and MMP2 expression in RCCC kidneys was significantly higher than that in normal kidneys. Expression of TGF-β1 and MMP2 in RCCC tissues was positively correlated with pathological grade and clinical stage. There was also a significant correlation between TGF-β1 and Msshese analyses indicate that upregulation of TGF-β1 and MMP2 expression may occur during the progression of RCCC. Thus, TGF-β1 and MMP2 may be useful molecular markers for evaluating prognosis in RCCC patients.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/1066896909331993

Reference22 articles.

1. Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-β receptor type II

2. Attenuated type II TGF-? receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination

3. Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas

4. Altered Pattern of Major Histocompatibility Complex Expression in Renal Carcinoma

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. G6PD upregulates Cyclin E1 and MMP9 to promote clear cell renal cell carcinoma progression;International Journal of Medical Sciences;2022

2. Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism;Current Research in Pharmacology and Drug Discovery;2022

3. SPARC is a key mediator of TGF‐β‐induced renal cancer metastasis;Journal of Cellular Physiology;2020-08-11

4. G6PD facilitates clear cell renal cell carcinoma invasion by enhancing MMP2 expression through ROS‑MAPK axis pathway;International Journal of Oncology;2020-04-08

5. Fibronectin Promotes Cell Growth and Migration in Human Renal Cell Carcinoma Cells;International Journal of Molecular Sciences;2019-06-07