Affiliation:
1. Departments of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York
2. Department of Urology, University of Rochester School of Medicine and Dentistry, Rochester, New York
Abstract
Renal oncocytosis is a rare condition in which a spectrum of oncocytic lesions, including oncocytomas, diffusely involve the kidney. Few cases have been reported and all were in adult patients. We report here such a case in a 12-year-old girl. In addition to the unusual age at presentation, this case is remarkable for its heterogeneous tumor morphology, with some areas containing chromophobe carcinoma-like cells. Electron microscopy, immunohistochemistry, Hale's colloidal iron staining, and cytogenetics were performed to further evaluate the different morphologic areas. Our results suggest that the cells in the chromophobe carcinoma-like areas do not fulfill all the diagnostic criteria of chromophobe carcinoma. We caution pathologists in making a malignant diagnosis in such cases, especially in younger patients.
Subject
Pathology and Forensic Medicine,Surgery,Anatomy
Cited by
12 articles.
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