Comparing Vitamin D Level Between Patients with Psoriasis and Healthy Individuals: A Systematic Review and Meta-Analysis

Author:

Moosazadeh Mahmood1,Damiani Giovanni23,Khademloo Mohammad4,Kheradmand Motahareh5,Nabinezhad-Male Fatemeh6,Hessami Amirhossein78ORCID

Affiliation:

1. Gastrointestinal Cancer Research Center, Non-communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran

2. Clinical Dermatology, IRCCS Galeazzi Orthopedic Institute, Milan, Italy

3. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

4. Department of Community Medicine, School of Medicine, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran

5. Health Sciences Research center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran

6. Mazandaran University of Medical Sciences, Sari, Iran

7. Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

8. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network, Tehran, Iran

Abstract

Background Psoriasis is nowadays regarded as a systemic inflammatory disorder. Among the topicals, vitamin D derivates are often applied on the skin for their anti-inflammatory and immune-modulatory properties. Vitamin D serum levels in psoriasis (PsO) patients are still debated and an eventual depletion may offer the rational to integrate anti-psoriatic therapies with oral vitamin D. Then, we aimed to perform a systematic review and meta-analysis on the current evidence towards serum vitamin D level in PsO. Methods We searched in PubMed, Scopus, Web of Sciences, ScienceDirect and Science Information Database (SID) using the terms “Vitamin D” and “Psoriasis” including manuscripts in English, Italian and Persian. Duplications were excluded using EndNote software and records were screened by title, abstract and full-text. Quality assessment of studies was assessed using Newcastle Ottawa Checklist (NOS). Psoriasis odds ratio (OR) and mean serum vitamin D levels were calculated and displayed in Forest-plots. Heterogeneity indexes were evaluated using I2 and Q. Sensitivity analysis and publication biases were also considered. Results From 3006 records extracted, after removing duplicates and analyzing full texts we finally included 19 manuscripts involving a total of 1387 PsO cases and 6939 controls. PsO patients exhibited a substantial odds ratio (3.07, 95% CI: 1.56-6.04) for lower serum vitamin D levels compared to the control group. Standardized Mean Difference (SMD) of vitamin D in PsO versus controls was −0.92 (−1.33 to −0.51). Conclusion Psoriatic patients displayed higher risk to have a vitamin D deficiency. Interventional studies to verify the preventive value are mandatory.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine

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