Pharmacokinetics of Cerivastatin in Renal Impairment Are Predicted by Low Serum Albumin Concentration Rather Than by Low Creatinine Clearance

Author:

Vormfelde Stefan V.,Mück Wolfgang,Freudenthaler Stefan M.,Heyen Petra,Schmage Nikolaus,Kuhlmann Jochen,Müller Gerhard A.,Gundert-Remy Ursula M.,Gleiter Christoph H.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference11 articles.

1. Absolute and relative bioavailability of the HMG-CoA reductase inhibitor cerivastatin;Mück;Int J Clin Pharmacol,1997

2. Cerivastatin, a new inhibitor of HMG-CoA reductase: pharmacokinetics in rats and dogs;Steinke;Jpn Pharmacol Ther,1996

3. Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved;Boberg;Drug Metab Dispos,1997

4. Cerivastatin: high enzyme affinity and active metabolites contribute to its high pharmacological activity (abstract);Bischoff;Atherosclerosis,1997

5. LC separation and induced fluorometric detection of rivastatin in blood plasma;Krol;J Pharm Biomed Anal,1993

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