Early and enduring: Targeting the endothelium for blood-brain barrier protection-Reference-Cited by-同舟云学术

Early and enduring: Targeting the endothelium for blood-brain barrier protection

Published:2024-06-21 Issue:9 Volume:44 Page:1674-1676
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Wu Silin¹^ORCID,Ren Xuefang Sophie¹^ORCID,Shi Yejie²^ORCID

Affiliation:

1. Department of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center, Houston, TX, USA

2. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

Abstract

The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/0271678X241264086

Reference10 articles.

1. Blood-brain barrier dysfunction and recovery after ischemic stroke

2. Ischemic brain edema: Emerging cellular mechanisms and therapeutic approaches

3. Endothelial peroxiredoxin-4 is indispensable for blood–brain barrier integrity and long-term functional recovery after ischemic stroke

4. Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

5. Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood–Brain Barrier