Point/counterpoint: Cerebrovascular resistance is a flawed concept

Author:

Ince Jonathan1ORCID,Minhas Jatinder S12ORCID,Panerai Ronney B12ORCID

Affiliation:

1. Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK

2. NIHR Leicester Biomedical Research Centre, Leicester, UK

Abstract

The relationship between cerebral blood flow and blood pressure is a critical part of investigation of cerebral autoregulation. Conventionally, cerebrovascular resistance (CVR) has been used to describe this relationship, but the underlying principles used for this method is flawed in real-world application for several reasons. Despite this, the use of CVR remains entrenched within current literature. This ‘Point/Counterpoint’ review provides a summary of the flaws in using CVR and explains the benefits of calculating the more accurate critical closing pressure (CrCP) and resistance-area product (RAP) parameters, with support of real-world data.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

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