Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease

Author:

Donahue Manus J1234,Achten Eric5,Cogswell Petrice M1,De Leeuw Frank-Erik6,Derdeyn Colin P7,Dijkhuizen Rick M8,Fan Audrey P9,Ghaznawi Rashid10,Heit Jeremy J11ORCID,Ikram M Arfan1213,Jezzard Peter14ORCID,Jordan Lori C15,Jouvent Eric16,Knutsson Linda1718,Leigh Richard19,Liebeskind David S20,Lin Weili21,Okell Thomas W14,Qureshi Adnan I22,Stagg Charlotte J23,van Osch Matthias JP24ORCID,van Zijl Peter CM1725,Watchmaker Jennifer M1,Wintermark Max11,Wu Ona2627,Zaharchuk Greg11,Zhou Jinyuan1725,Hendrikse Jeroen10

Affiliation:

1. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

2. Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA

3. Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA

4. Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA

5. Department of Radiology and Nuclear Medicine, Universiteit Gent, Gent, Belgium

6. Radboud University, Nijmegen Medical Center, Donders Institute Brain Cognition & Behaviour, Center for Neuroscience, Department of Neurology, Nijmegen, The Netherlands

7. Department of Radiology and Neurology, University of Iowa, Iowa City, IA, USA

8. Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands

9. Department of Radiology, Stanford University, Stanford, CA, USA

10. Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands

11. Department of Radiology, Neuroimaging and Neurointervention Division, Stanford University, CA, USA

12. Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

13. Department of Radiology, Erasmus MC, Rotterdam, The Netherlands

14. Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK

15. Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA

16. Department of Neurology, AP-HP, Lariboisière Hospital, Paris, France

17. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

18. Department of Medical Radiation Physics, Lund University, Lund, Sweden

19. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

20. Neurovascular Imaging Research Core, UCLA, Los Angeles, CA, USA

21. Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

22. Department of Neurology, Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA

23. Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK

24. Department of Radiology, Leiden Medical Center, Leiden, The Netherlands

25. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA

26. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA

27. Department of Radiology, Harvard Medical School, Boston, MA, USA

Abstract

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

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