Association Between Growth Hormone Receptor Gene Polymorphisms rs6180, rs6182, and rs6184 and Craniofacial Parameters in Indian Population

Abstract

Objective/Background Craniofacial growth and development is influenced by growth hormone, which is in turn facilitated by the growth hormone receptor (GHR). GHR gene polymorphisms have been found to be associated with mandibular morphology and skeletal facial profiles in various populations. The aim of this study was to determine the association of single nucleotide polymorphisms (SNP) of GHR gene rs6180, rs6182, and rs6184 with maxillomandibular parameters in the Indian population. Setting and Sample Population A cross sectional study was conducted on 174 male and female Indian subjects in the age range of 20 to 32 years who reported for orthodontic treatment. Material and Methods Venous blood and lateral cephalogram were collected from each participant for genetic and cephalometric analysis. Genotypes of each SNP were identified by polymerase chain reaction—restriction fragment length polymorphism. Independent t test and Analysis of Variance (ANOVA) were done for intra and inter group comparisons with SPSS software. Results SNPs rs6180, and rs6182 were found to be associated with sagittal position and length of maxilla and mandible, anterior facial height, and growth pattern. SNP rs6184 did not have any significant association with the craniofacial parameters. Conclusion The results suggest that the GHR gene might be a candidate gene for maxillomandibular morphology in the Indian population.