Affiliation:
1. Queen Elizabeth University Hospital, Glasgow, UK
Abstract
Nebulisers are devices that reduce a body of liquid into a fine aerosol suitable for inhalation. Utilising the efficiency of pulmonary drug absorption, they offer a safe and powerful modality for local and systemic drug delivery in the treatment of critical illness. In comparison to conventional jet (JN) and ultrasonic nebulisers (USN), the advent of vibrating mesh nebulisers (VMN) has significantly improved the therapeutic potential of modern devices. This review article aims to summarise the history and evolution of nebulisers from first inception through to the modern vibrating mesh technology. It provides an overview on the basic science of nebulisation and pulmonary drug delivery, and the current use of nebulised therapies in critical care.
Subject
Critical Care and Intensive Care Medicine,Critical Care Nursing
Reference90 articles.
1. Deposition of Inhaled Particles in the Lungs
2. Scottish Intercollegiate Guidelines Network, British Thoracic Society. SIGN158: British guideline on the management of asthma, https://www.sign.ac.uk/media/1773/sign158-updated.pdf (2019, accessed 9 May 2023).
3. Diagnosis and management of inhalation injury: an updated review
4. Fundamentals of aerosol therapy in critical care