Clinical and Laboratory Evaluation of Hemocarboadsorption in Autoimmune Bullous Dermatoses-Reference-Cited by-同舟云学术

Clinical and Laboratory Evaluation of Hemocarboadsorption in Autoimmune Bullous Dermatoses

Published:1990-03 Issue:3 Volume:13 Page:181-188
ISSN:0391-3988
Container-title:The International Journal of Artificial Organs
language:en
Short-container-title:Int J Artif Organs

Author:

Grando S.A.¹²,Drannik G.N.³,Glukhenky B.T.²,Kostromin A.P.⁴,Romanenko A.B.¹,Chayun O.A.¹,Chernyavski A.I.²

Affiliation:

1. Unit of Immunodermatology & Extracorporeal Detoxification, Kiev State University - U.S.S.R.

2. Chair of Dermato-Venereology, Kiev State Advanced Training Institute for Doctors, Kiev State University - U.S.S.R.

3. Centre for Clinical and Experimental Immunology, the UkrSSR Academy of Sciences and Ministry of Health, Kiev State University - U.S.S.R.

4. Laboratory of Immunobiology, Kiev State University - U.S.S.R.

Abstract

Hemocarboadsorption (HCA) with the following immunosuppressive therapy was used to treat 48 patients with pemphigus vulgaris (PV) and 31 patients with bullous pemphigoid (BP) in the acute phase. The levels of autoantibodies, eicosanoids, endoproteases and their inhibitors as well as interleukin (IL) 1 and IL 2 production and absorption of exogenous IL 2 were examined in the treatment dynamics. The therapeutic effect of HCA was displayed in prompt disease remission in 43 PV and 29 BP patients. Clinical improvement was accompanied by antibody elimination and interleukin cascade reaction normalization. HCA resulted in growth of patients’ serum immunosuppressive activity. It was concluded that HCA has some immunoregulatory effect.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/039139889001300309

Reference40 articles.

1. Bullous Pemphigoid

2. Pemphigus

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid;Autoimmunity Reviews;2019-05

2. Pemphigus autoimmunity: Hypotheses and realities;Autoimmunity;2011-09-23

3. Pemphigus in the XXI Century: New life to an old story;Autoimmunity;2006-01

4. New Approaches to the Treatment of Pemphigus;Journal of Investigative Dermatology Symposium Proceedings;2004-01

5. Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes;Journal of Biological Chemistry;2004-01