Suppression of Neutrophil Superoxide Production by Conventional Peritoneal Dialysis Solution-Reference-Cited by-同舟云学术

Suppression of Neutrophil Superoxide Production by Conventional Peritoneal Dialysis Solution

Published:1988-09 Issue:5 Volume:11 Page:351-354
ISSN:0391-3988
Container-title:The International Journal of Artificial Organs
language:en
Short-container-title:Int J Artif Organs

Author:

Ing B.L.¹²,Gupta D.K.¹²,Nawab Z.M.¹²,Zhou F-Q.¹²,Rahman M.A.¹²,Daugirdas J.T.¹²

Affiliation:

1. Department of Medicine, Veterans Administration Hospital, Hines.

2. Loyola University Stritch School of Medicine, Maywood, Illinois - U.S.A.

Abstract

The pH of conventional peritoneal dialysis solution is normally in the range of 5.0 to 5.5, because acid has been added during the manufacturing process to prevent caramelization of dextrose during sterilization. We studied the effects of normalizing the pH of conventional peritoneal dialysis solution on superoxide production by normal human neutrophils. At a pH of 6.0, superoxide generation was 4.07±2.56 (SD) nanomoles per million cells. With normalization of pH to 7.4, superoxide production was 19.3± 7.3 (p < 0.001). The results suggest that the unphysiologic acidity of conventional peritoneal dialysis solution has deleterious consequences on neutrophil superoxide formation.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/039139888801100508

Reference15 articles.

1. Effects of the composition of peritoneal dialysis fluid on chemiluminescence, phagocytosis, and bactericidal activity in vitro

2. Isolation of Lymphocytes, Granulocytes and Macrophages

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