Hybrid liver support system in a short term application on hepatectomized pigs

Author:

Gerlach J.1,Trost T.1,Ryan C.J.2,Meißler M.1,Hole O.1,Müller C.3,Neuhaus P.1

Affiliation:

1. Chirurgische Klinik, Freie Universität Berlin -Germany

2. Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London - UK

3. Institut f. Klinische Chemie und Biochemie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin -Germany

Abstract

A short term application of a hybrid liver support system in circuits with continuous plasma-separation was investigated in a model of hepatectomized pigs under general anesthesia. Primary pig hepatocytes were immobilized in a bioreactor with three independent capillary systems. An immune barrier is achieved by avoiding the direct contact of blood cells with the hepatocytes by a plasmaseparation step and by an outflow filtration within the reactor. In three groups (hepatectomized pigs and system with- or without hepatocytes as well as untreated pigs with system without hepatocytes), the short term metabolism of the reactors was positively demonstrated by investigating ammonia detoxification, phenylalanine- and lactate metabolism. Limitations of the presented model are discussed.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering

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