The Effect of Hemoperfusion over Uncoated and Polymer — Coated Charcoal on Hematological Levels in the Conscious Rat-Reference-Cited by-同舟云学术

The Effect of Hemoperfusion over Uncoated and Polymer — Coated Charcoal on Hematological Levels in the Conscious Rat

Published:1982-07 Issue:4 Volume:5 Page:249-256
ISSN:0391-3988
Container-title:The International Journal of Artificial Organs
language:en
Short-container-title:Int J Artif Organs

Author:

Ryan C.J.¹,Courtney J.M.²

Affiliation:

1. Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

2. Bioengineering Unit, University of Strathclyde, Glasgow, U.K.

Abstract

An investigation has been made of the suitability of a rat hemoperfusion system for the evaluation of hematological changes induced by charcoal hemoperfusion. The investigation studied the influence on erythrocyte, leucocyte and thrombocyte levels of repeated hemoperfusion over Norit RBX1 charcoal, hemoperfusion over polymer-coated Norit RBX1 and hemoperfusion over uncoated spherical charcoal. Controls included animals subjected to hemoperfusion through empty columns and animals cannulated only. The results indicate that changes in erythrocyte and leucocyte levels are due principally to passage of blood through the extracorporeal circuit rather than contact with the adsorbent but that changes in thrombocyte levels are dependent on the type of charcoal and the nature and extent of polymer coating. The investigation suggests that the rat hemoperfusion system is a suitable procedure for the assessment of the compatibility of adsorbents to be used in hemoperfusion.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1177/039139888200500408

Reference37 articles.

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