Rheopheresis in Vascular Diseases

Author:

Ferrannini M.1,Vischini G.1,Staffolani E.1,Scaccia F.2,Miani N.1,Parravano M.C.3,Louis M.M.1,Splendiani G.1,Di Daniele N.1

Affiliation:

1. Nephrology and Dialysis Unit, Tor Vergata University, Rome - Italy

2. Nephrology and Dialysis Unit, Umberto I Hospital, Frosinone - Italy

3. Ophthalmology Unit, Tor Vergata University, Rome - Italy

Abstract

Background Endothelial dysfunction is a common condition in many microvascular diseases, such as Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD). Rheopheresis therapy improves ematic viscosity, shear stress and endothelial function while decreasing fibrinogen, LDL-cholesterol and alpha-2-macroglobulin levels. Objective To evaluate the therapeutic efficacy of rheopheresis in patients with microcirculatory diseases. Materials and Methods Eight patients (7 male and 1 female) were treated with rheopheresis: 3 males were affected by AMD, 4 male and 1 female by uremia and PAOD. We used Membrane Differential Filtration (MDF) with an ethinylvinylalcohol copolymer membrane as plasmafiltrator. Patients with AMD were treated once a week for ten weeks. Patients affected with PAOD were treated twice weekly for 3 weeks and then were placed on a once-a-week program. Results In all treated patients with AMD, visual acuity improved. In all patients affected with PAOD, we observed a complete resolution of pain; 3 out of 5 had a complete remission of ulcers. There was partial reduction of ulcers in the other patients and no adverse effects were observed. Conclusion: Rheopheresis is a safe, effective form of hemorheotherapy

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering

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