Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report

Author:

Motl Robert W1ORCID,Russell Daniel I2,Pilutti Lara A3ORCID,Metse Alexandra P45,Marck Claudia H6ORCID,Chan Bryan78ORCID,Zheng Peixuan1ORCID,Learmonth Yvonne C91011

Affiliation:

1. Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA

2. School of Psychology, Murdoch University, Murdoch, WA, Australia

3. Interdisciplinary School of Health Sciences, Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada

4. Discipline of Psychology, School of Health, University of the Sunshine Coast, Sippy Downs, QLD, Australia

5. School of Psychological Sciences, College of Engineering, Science and Environment, The University of Newcastle, Callaghan, NSW, Australia

6. Disability and Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia

7. Murdoch University Library, Murdoch, WA, Australia

8. Discipline of Libraries, Archives, Records and Information Science, School of Media, Creative Arts and Social Inquiry, Faculty of Humanities, Curtin University, Perth, WA, Australia

9. School of Allied Health (Exercise Science), Murdoch University, Murdoch, WA, Australia; Perron Institute for Neurological and Translational Science, Perth, WA, Australia

10. Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Murdoch, WA, Australia

11. Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia

Abstract

We documented reporting and rates of drop-out, adherence, and compliance from 40 randomized controlled trials (RCTs) included in our meta-analysis on safety of exercise training (ET) in MS. We adopted definitions and metrics of adherence and compliance provided by the MoXFo adherence group. Drop-out was reported in 100% of the RCTs and approximated 10% for intervention and control conditions. Adherence and compliance were reported in approximately 50% and 10% of the RCTs, respectively, and approximated 80% and 70%, respectively. Standardized metrics for reporting adherence and compliance are important in future RCTs for understanding the impact on outcomes and translation of research evidence into practice.

Publisher

SAGE Publications

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