Piet Mondrian’s trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011-Reference-Cited by-同舟云学术

Piet Mondrian’s trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011

Published:2013-01 Issue:1 Volume:19 Page:5-14
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Steinman Lawrence¹,Axtell Robert C¹,Barbieri Donald¹,Bhat Roopa¹,Brownell Sara E¹,de Jong Brigit A²,Dunn Shannon E³,Grant Jacqueline L¹,Han May H¹,Ho Peggy P¹,Kuipers Hedwich F¹,Kurnellas Michael P¹,Ousman Shalina S⁴,Rothbard Jonathan B¹

Affiliation:

1. Department of Neurology and Neurological Sciences, Stanford University, USA

2. Department of Neurology (HP935), Radboud University Nijmegen Medical Centre, The Netherlands

3. Department of Immunology, University of Toronto, Canada

4. Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Canada

Abstract

Four questions were posed about multiple sclerosis (MS) at the 2011 Charcot Lecture, Oct. 22, 2011. 1. The Male/Female Disparity: Why are women developing MS so much more frequently than men? 2. Neuronal and Glial Protection: Are there guardian molecules that protect the nervous system in MS? 3. Predictive Medicine: With all the approved drugs, how can we rationally decide which one to use? 4. The Precise Scalpel vs. the Big Hammer for Therapy: Is antigen-specific therapy for demyelinating disease possible? To emphasize how our views on the pathogenesis and treatment of MS are evolving, and given the location of the talk in Amsterdam, Piet Mondrian’s progressive interpretations of trees serve as a heuristic.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458512470730

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