Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review

Abstract

Background: Dietary intervention in multiple sclerosis carries potential therapeutic implications. While studies utilizing animal models of multiple sclerosis (MS) have demonstrated intriguing findings, well-designed clinical trials are few in number. Objective: The objective of this study is to review the animal model and clinical literature regarding dietary factors in experimental autoimmune encephalitis (EAE) and MS. Methods: This manuscript provides a comprehensive review of current animal model and clinical knowledge related to dietary factors in MS. Results: While there is currently little data for any specific diet in MS, there is growing evidence that certain dietary factors may influence the disease. Conclusions: Definitive information regarding dietary factors as a modifiable risk factor in MS will require larger randomized clinical trials.