Smoking and its interaction with genetics in MS etiology-Reference-Cited by-同舟云学术

Smoking and its interaction with genetics in MS etiology

Published:2018-09-25 Issue:2 Volume:25 Page:180-186
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Hedström Anna K¹

Affiliation:

1. Department of Clinical Neuroscience and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Abstract

The etiology of multiple sclerosis (MS) involves multifaceted interactions between genetic loci and environmental factors. Smoking is an important risk factor for MS that overall increases the risk of the disease with approximately 50%. However, the precise effects of smoking on MS development vary considerably in different contexts and in different populations. This review focuses on the influence of smoking on MS risk and its interaction with genetics in MS etiology. The possible biological mechanisms are presented in this paper. Further research is needed to establish the mechanisms of causality and to explore preventive strategies.

Funder

Neuro Sweden

Svenska Sällskapet fér Medicinsk Forskning

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458518801727

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1. Class II HLA interactions modulate genetic risk for multiple sclerosis

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