SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study
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Published:2021-07-30
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Volume:
Page:135245852110353
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ISSN:1352-4585
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Container-title:Multiple Sclerosis Journal
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language:en
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Short-container-title:Mult Scler
Author:
Sormani Maria Pia1ORCID, Schiavetti Irene2, Landi Doriana3, Carmisciano Luca2ORCID, De Rossi Nicola4, Cordioli Cinzia4, Moiola Lucia5, Radaelli Marta6, Immovilli Paolo7, Capobianco Marco8, Brescia Morra Vincenzo9, Trojano Maria10ORCID, Tedeschi Gioacchino11, Comi Giancarlo12, Battaglia Mario Alberto13, Patti Francesco14ORCID, Fragoso Yara Dadalti15ORCID, Sen Sedat16ORCID, Siva Aksel17, Furlan Roberto18ORCID, Salvetti Marco19ORCID, Abbadessa Gianmarco, Aguglia Umberto, Allegorico Lia, Allegri Rossi Beatrice Maria, Amato Maria Pia, Annovazzi Pietro, Antozzi Carlo, Appendino Lucia, Arena Sebastiano, Baione Viola, Balgera Roberto, Barcella Valeria, Baroncini Damiano, Barrilà Caterina, Battaglia Mario A., Bellacosa Alessandra, Bellucci Gianmarco, Bergamaschi Roberto, Bergamaschi Valeria, Bezzini Daiana, Biolzi Beatrice, Bisecco Alvino, Bonavita Simona, Borriello Giovanna, Bosa Chiara, Bosco Antonio, Bovis Francesca, Bozzali Marco, Brambilla Laura, Brescia Morra Vincenzo, Brichetto Giampaolo, Buccafusca Maria, Bucciantini Elisabetta, Bucello Sebastiano, Buscarinu Maria Chiara, Cabboi Maria Paola, Calabrese Massimiliano, Calabria Francesca, Caleri Francesca, Camilli Federico, Caniatti Luisa Maria, Cantello Roberto, Capobianco Marco, Capra Ruggero, Capuano Rocco, Carmisciano Luca, Carta Patrizia, Cavalla Paola, Celani Maria Grazia, Cellerino Maria, Cerqua Raffaella, Chisari Clara, Clerici Raffaella, Clerico Marinella, Cocco Eleonora, Cola Gaia, Comi Giancarlo, Confalonieri Paolo, Conte Antonella, Conti Marta Zaffira, Cordano Christian, Cordera Susanna, Cordioli Cinzia, Corea Francesco, Correale Claudio, Cottone Salvatore, Crescenzo Francesco, Curti Erica, d’Ambrosio Alessandro, D’Amico Emanuele, Danni Maura Chiara, d’Arma Alessia, Dattola Vincenzo, de Biase Stefano, De Luca Giovanna, De Mercanti Stefania Federica, De Mitri Paolo, De Rossi Nicola, De Stefano Nicola, Della Cava Marco, di Napoli Mario, Di Sapio Alessia, Docimo Renato, Dutto Anna, Evangelista Luana, Fanara Salvatore, Ferraro Diana, Ferrò Maria Teresa, Filippi Massimo, Fioretti Cristina, Fratta Mario, Frau Jessica, Fronza Marzia, Furlan Roberto, Gajofatto Alberto, Gallo Antonio, Gallo Paolo, Gasperini Claudio, Ghazaryan Anna, Giometto Bruno, Gobbin Francesca, Govone Flora, Granella Franco, Grange Erica, Grasso Maria Grazia, Guareschi Angelica, Guaschino Clara, Guerrieri Simone, Guidetti Donata, Iaffaldano Pietro, Ianniello Antonio, Iasevoli Luigi, Immovilli Paolo, Imperiale Daniele, Infante Maria Teresa, Inglese Matilde, Iodice Rosa, Iovino Aniello, Konrad Giovanna, Landi Doriana, Lanzillo Roberta, Lapucci Caterina, Lavorgna Luigi, L’Episcopo Maria Rita, Leva Serena, Liberatore Giuseppe, Lo Re Marianna, Longoni Marco, Lopiano Leonardo, Lorefice Lorena, Lucchini Matteo, Lus Giacomo, Maimone Davide, Malentacchi Maria, Mallucci Giulia, Malucchi Simona, Mancinelli Chiara Rosa, Mancinelli Luca, Manganotti Paolo, Maniscalco Teresa Giorgia, Mantero Vittorio, Marangoni Sabrina, Marastoni Damiano, Marfia Alessandra Girolama, Marinelli Fabiana, Marti Alessandro, Martinelli Boneschi Filippo, Masserano Zoli Federco, Matta Francesca, Mendozzi Laura, Meucci Giuseppe, Miante Silvia, Miele Giuseppina, Milano Eva, Mirabella Massimiliano, Missione Rosanna, Moccia Marcello, Moiola Lucia, Montepietra Sara, Monti Bragadin Margherita, Montini Federico, Motta Roberta, Nardone Raffaele, Nicoletti Carolina Gabri, Nobile-Orazio Eduardo, Nozzolillo Agostino, Onofrj Marco, Orlandi Riccardo, Palmieri Anna, Paolicelli Damiano, Pasquali Livia, Pastò Luisa, Patti Francesco, Pedrazzoli Elisabetta, Perini Paola, Pesci Ilaria, Petracca Maria, Petrone Alfredo, Piantadosi Carlo, Pietroboni Anna M., Pinardi Federica, Ponzano Marta, Portaccio Emilio, Pozzato Mattia, Pozzilli Carlo, Prosperini Luca, Protti Alessandra, Radaelli Marta, Ragonese Paolo, Rasia Sarah, Realmuto Sabrina, Repice Anna, Rigoni Eleonora, Rilla Maria Teresa, Rinaldi Francesca, Romano Calogero Marcello, Ronzoni Marco, Rovaris Marco, Ruscica Francesca, Sabattini Loredana, Salemi Giuseppe, Salvetti Marco, Saraceno Lorenzo, Sartori Alessia, Sartori Arianna, Sbragia Elvira, Scandellari Cinzia, Scarano Giuditta Ilaria, Scarano Valentina, Schiavetti Irene, Schillaci Valentina, Sessa Maria, Sgarito Caterina, Sibilia Grazia, Siciliano Gabriele, Signori Alessio, Signoriello Elisabetta, Sinisi Leonardo, Sireci Francesca, Sola Patrizia, Solaro Claudio, Sormani Maria Pia, Sotgiu Stefano, Sparaco Maddalena, Stromillo Maria Laura, Strumia Silvia, Susani Laura Emanuela, Tabiadon Giulietta, Teatini Francesco, Tedeschi Gioacchino, Tomassini Valentina, Tonietti Simone, Torri Clerici Valentina, Tortorella Carla, Toscano Simona, Totaro Rocco, Trojano Maria, Trotta Maria, Turano Gabriella, Ulivelli Monica, Valentino Manzo, Vaula Giovanna, Vecchio Domizia, Vercellino Marco, Verrengia Elena Pinuccia, Vianello Marika, Virgilio Eleonora, Vitetta Francesca, Vollaro Stefano, Zaffaroni Mauro, Zampolini Mauro, Zarbo Ignazio Roberto, Zito Antonio, Zuliani Luigi
Affiliation:
1. Department of Health Sciences, University of Genoa, Genoa, Italy/IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2. Department of Health Sciences, University of Genoa, Genoa, Italy 3. Multiple Sclerosis Clinical and Research Unit, Department of Systems Medicine, Tor Vergata University, Rome, Italy 4. Centro Sclerosi Multipla, ASST Spedali Civili di Brescia, Montichiari, Italy 5. Department of Neurology, Multiple Sclerosis Center, IRCCS Ospedale San Raffaele, Milan, Italy 6. Department of Neurology and Multiple Sclerosis Center, ASST ‘Papa Giovanni XXIII’, Bergamo, Italy 7. Multiple Sclerosis Center, Ospedale Guglielmo da Saliceto, Piacenza, Italy 8. Department of Neurology, Regional Referral Multiple Sclerosis Centre, University Hospital San Luigi, Torino, Italy 9. University of Naples Federico II, Naples, Italy 10. Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy 11. Department of Advanced Medical and Surgical Sciences, University of Campania, Napoli, Italy 12. Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Milan, Italy 13. Research Department, Italian Multiple Sclerosis Foundation, Genoa, Italy/Department of Life Sciences, University of Siena, Siena, Italy 14. Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Catania, Italy/Centro Sclerosi Multipla, Policlinico Catania, University of Catania, Catania, Italy 15. Universidade Metropolitana de Santos, Santos, Brazil 16. School of Medicine, Ondokuz Mayis University, Samsun, Turkey 17. School of Medicine, Istanbul University, Cerrahpasa, Istanbul, Turkey 18. Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milano, Italy/Italian Neuroimmunology Association-AINI, Florence, Italy 19. Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy/Unit of Neurology, IRCCS Neuromed, Isernia, Italy
Abstract
Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination.
Publisher
SAGE Publications
Subject
Clinical Neurology,Neurology
Cited by
41 articles.
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