Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination-possible markers for an antibody-mediated process-Reference-Cited by-同舟云学术

Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination-possible markers for an antibody-mediated process

Published:2001-06 Issue:3 Volume:7 Page:173-177
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Brück Wolfgang¹,Neubert Katrin²,Berger Thomas³,Weber Joerg R²

Affiliation:

1. Department of Neuropathology, Charité, Humboldt-Universität, Berlin, Germany

2. Department of Neurology, Charité, Humboldt-Universität, Berlin, Germany

3. Department of Neurology, University of Innsbruck, Austria

Abstract

The present report describes immunopathological, radiologcal and serological characteristics of antibody-mediated demyelination in a multiple sclerosis (MS) case with the main findings: (1) immunoglobulin and complement deposits in areas of active demyelination accompanied by massive macrophage activation; (2) ring-enhancing lesions in T1-weighted MRI after gadolinium application; (3) high titers of serum anti-myelin antibodies; and (4) signs of macrophage activation in the serum. Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/135245850100700307

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