A new look at cognitive functioning in pediatric MS

Author:

Krupp Lauren B1ORCID,Waubant Emmanuelle2,Waltz Michael3,Casper T Charles3,Belman Anita1,Wheeler Yolanda4,Ness Jayne4,Graves Jennifer5,Gorman Mark6,Benson Leslie6,Mar Soe7,Goyal Manu7,Schreiner Teri8,Weinstock-Guttman Bianca9ORCID,Rodriguez Moses10,Tillema Jan-Mendelt10,Lotze Timothy11,Aaen Greg12,Rensel Mary13ORCID,Rose John3,Chitinis Tanuja14ORCID,George Allan1,Charvet Leigh E1ORCID,

Affiliation:

1. Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU Langone Health, New York, NY, USA

2. Pediatric Multiple Sclerosis Center, University of California San Francisco, San Francisco, CA, USA

3. Data Coordinating and Analysis Center, The University of Utah, Salt Lake City, UT, USA

4. Center for Pediatric-Onset Demyelinating Disease, The University of Alabama at Birmingham, Birmingham, AL, USA

5. Pediatric Multiple Sclerosis Center, University of California San Diego, San Diego, CA, USA

6. Pediatric Multiple Sclerosis and Related Disorders Program at Boston Children’s Hospital, Boston, MA, USA

7. Washington University in St. Louis, St. Louis, MO, USA

8. Rocky Mountain Multiple Sclerosis Center, Children’s Hospital Colorado, University of Colorado Denver, Aurora, CO, USA

9. Jacobs Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, NY, USA

10. Mayo Clinic Pediatric Multiple Sclerosis Center, Mayo Clinic, Rochester, MN, USA

11. The Blue Bird Circle Clinic for Multiple Sclerosis, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA

12. Pediatric Multiple Sclerosis Center, Loma Linda University Children’s Hospital, Loma Linda, CA, USA

13. Cleveland Clinic Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA

14. Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston, MA, USA

Abstract

Objective: Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls. Methods: Consecutive relapsing pediatric MS participants from the United States Network of Pediatric MS Centers were compared with pediatric healthy controls and adults with relapsing MS. Participants were compared on two screening batteries: the Brief International Cognitive Assessment for MS and the Cogstate Brief Battery. Results were transformed to age-normative z scores. Results: The pediatric groups (MS vs. Healthy Controls) did not differ on either battery’s composite mean score or individual test scores ( ps > 0.32), nor in the proportions impaired on either battery, Brief International Cognitive Assessment for MS (26% vs. 24%, p = 0.83); Cogstate Brief Battery (26% vs. 32%, p = 0.41). The pediatric versus adult MS group even after controlling for differences in disease duration performed better on the Brief International Cognition Assessment for MS composite ( p = 0.03), Symbol Digit Modalities Test ( p = 0.02), Rey Auditory Verbal Learning Test ( p = 0.01), and Cogstate choice reaction time ( p < 0.001). Conclusion: Pediatric MS patients do not differ from healthy pediatric controls on cognitive screens but perform better than adults with MS.

Funder

National Multiple Sclerosis Society

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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