Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men-Reference-Cited by-同舟云学术

Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men

Published:2020-06-08 Issue:1 Volume:27 Page:147-150
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Xu Yin¹,Hiyoshi Ayako¹,Brand Judith S¹,Smith Kelsi A²^ORCID,Bahmanyar Shahram³,Alfredsson Lars⁴,Olsson Tomas⁵,Montgomery Scott⁶

Affiliation:

1. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden

2. Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden/Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

3. Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden/Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden

4. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden/Centre for Occupational and Environmental Medicine, Stockholm, Sweden

5. Department of Clinical Neuroscience, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

6. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden/Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden/Department of Epidemiology and Public Health, University College London, London, UK

Abstract

Background: Evidence for the association between body mass index (BMI) and multiple sclerosis (MS) among men remains mixed. Objective and methods: Swedish military conscription and other registers identified MS after age of 20 years and BMI at ages 16–20 years ( N = 744,548). Results: Each unit (kg/m2) BMI increase was associated with greater MS risk (hazard ratio and 95% confidence interval = 1.034, 1.016–1.053), independent of physical fitness (1.021, 1.001–1.042). Categorised, overweight and obesity were associated with statistically significant raised MS risk compared to normal weight, but not after adjustment for physical fitness. Conclusion: MS risk rises with increasing BMI, across the entire BMI range.

Funder

economic and social research council

Nyckelfonden

vetenskapsràdet

International Centre for Life Course Studies

hjãrnfonden

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458520928061