Gender identity disorders and multiple sclerosis risk: A national record-linkage study-Reference-Cited by-同舟云学术

Gender identity disorders and multiple sclerosis risk: A national record-linkage study

Published:2016-07-11 Issue:13 Volume:22 Page:1759-1762
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Pakpoor Julia¹,Wotton Clare J¹,Schmierer Klaus²,Giovannoni Gavin²,Goldacre Michael J¹

Affiliation:

1. Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, UK

2. Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK; Department of Neurology, Barts Health NHS Trust, The Royal London Hospital, London, UK

Abstract

Background: An altered balance of gonadal hormones in males with gender identity disorders (GIDs) may increase multiple sclerosis (MS) risk both inherently and secondary to treatment in undergoing male-to-female conversion. Objective: We investigated any association between GIDs and MS through analysis of record-linked hospital statistics. Method: Analysis of English Hospital Episode Statistics, 1999–2012. Results: The adjusted rate ratio (RR) of MS following GIDs in males was 6.63 (95% confidence interval (95% CI) = 1.81–17.01, p = 0.0002). The RR of MS following GIDs in females was 1.44 (95% CI = 0.47–3.37, p = 0.58). Conclusion: We report a strong association between GIDs and MS in male-to-females, supporting a potential role for low testosterone and/or feminising hormones on MS risk in males.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458515627205

Reference10 articles.

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