Affiliation:
1. Colton Center for Autoimmunity, New York University School of Medicine, New York, NY, USA
2. Rheumatology Unit, Department of Medicine, School of Medical Science, State University of Campinas, Campinas, Brazil
Abstract
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are two common autoimmune rheumatic diseases that vary in severity, clinical presentation, and disease course between individuals. Molecular and genetic studies of both diseases have identified candidate genes and molecular pathways that are linked to various disease outcomes and treatment responses. Currently, patients can be grouped into molecular subsets in each disease, and these molecular categories should enable precision medicine approaches to be applied in rheumatic diseases. In this article, we will review key lessons learned about disease heterogeneity and molecular characterization in rheumatology, which we hope will lead to personalized therapeutic strategies.
Funder
conselho nacional de desenvolvimento científico e tecnológico
National Institutes of Health
Childhood Arthritis and Rheumatism Research Alliance
CureJM Foundation
Judith and Stewart Colton Center for Autoimmunity
lupus research alliance
clinical and translational science institute, new york university
Fundação Apoio À Pesquisa Estado São Paulo-Brasil
coordenação de aperfeiçoamento de pessoal de nível superior
rheumatology research foundation
arthritis national research foundation
Subject
Clinical Neurology,Neurology
Cited by
14 articles.
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