Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC)

Author:

Jakimovski Dejan1ORCID,Kavak Katelyn S2,Zakalik Karen2,Coetzee Timothy3ORCID,Gottesman Malcolm4,Coyle Patricia K5,Zivadinov Robert6ORCID,Weinstock-Guttman Bianca2ORCID

Affiliation:

1. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA

2. Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York, Buffalo, NY, USA

3. National Multiple Sclerosis Society, New York, NY, USA

4. NYU Langone Ambulatory Care, East Meadow. East Meadow, NY, USA

5. State University of New York at Stony Brook, Stony Brook, NY, USA

6. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, USA

Abstract

Judicious multiple sclerosis (MS) diagnosis and early start of disease modifying therapy significantly improves long-term disability outcomes in persons with MS (pwMS). Retrospective analysis based on 25-year New York State MS Consortium (NYSMSC) data determined the effect of changes in the respective diagnostic criteria in shortening the time between symptom onset to MS diagnosis. Based on 9378 current and historical MS cases, there was a significant decrease in time to diagnosis in pwMS from 1982–2001 to >2017 periods (average 4.2 vs. 1.1 years, p < 0.001). Additional improvements and better implementation of the MS diagnostic criteria can further decrease the diagnosis lag.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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