Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis-Reference-Cited by-同舟云学术

Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis

Published:2014-12-22 Issue:11 Volume:21 Page:1463-1467
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Sorosina Melissa¹,Esposito Federica²,Guaschino Clara²,Clarelli Ferdinando¹,Barizzone Nadia³,Osiceanu Ana Maria¹,Brambilla Paola¹,Mascia Elisabetta¹,Cavalla Paola⁴,Gallo Paolo⁵,Martinelli Vittorio⁶,Leone Maurizio⁷,Comi Giancarlo²,D’Alfonso Sandra³,Martinelli Boneschi Filippo², ,

Affiliation:

1. Laboratory of Genetics of Neurological complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

2. Laboratory of Genetics of Neurological complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy/Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

3. Interdisciplinary Research Centre of Autoimmune Disease IRCAD, University of Eastern Piedmont, Novara, Italy/Department of Health Sciences, University of Eastern Piedmont, Novara, Italy

4. Multiple Sclerosis Centre, AOUS Giovanni Battista di Torino, Department of Neurosciences, University of Turin, Italy

5. The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Padua, Italy

6. Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

7. Interdisciplinary Research Centre of Autoimmune Disease IRCAD, University of Eastern Piedmont, Novara, Italy

Abstract

We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) ( n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= −0.1; p=5 × 10−3) and a later age at onset in PrMS cases (rho=0.07; p=0.15) ( p of difference of regression=1.4 × 10−2). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458514561910

Reference13 articles.

1. Natural history of primary progressive multiple sclerosis

2. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

3. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis

4. Genotype–phenotype correlation for non-HLA disease associated risk alleles in multiple sclerosis

5. Multiple Sclerosis Susceptibility-Associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Role of Parental Consanguinity and Familial Aggregation in Development of Multiple Sclerosis: A Case-control Study;2024-03-28

2. Discussing the potential for progression with patients newly diagnosed with multiple sclerosis: When, how, and why?;Multiple Sclerosis and Related Disorders;2022-12

3. Trends in the environmental risks associated with earlier onset in multiple sclerosis;Multiple Sclerosis and Related Disorders;2022-12

4. Genetics of multiple sclerosis: lessons from polygenicity;The Lancet Neurology;2022-09

5. A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility;Journal of Neurology;2022-05-12