Meeting Review: The management of multiple sclerosis in children: a European view

Author:

Ghezzi Angelo1,Banwell Brenda2,Boyko Alexey3,Amato Maria Pia4,Anlar Banu5,Blinkenberg Morten6,Boon Maartje7,Filippi Massimo8,Jozwiak Sergiusz9,Ketelslegers Immy10,Kornek Barbara11,Ming Lim 12,Lindstrom Eva13,Nadj Congor14,Neuteboom Rinze10,Rocca Maria A8,Rostasy Kevin15,Tardieu Marc16,Wassmer Evangeline17,Catsman-Berrevoets Coriene10,Hintzen Rogier18

Affiliation:

1. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy

2. Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

3. Russian State Medical University, Department of Neurology and Neurosurgery, Moscow, Russia

4. University of Florence, Department of Neurological and Psychiatric Sciences, Florence, Italy

5. Hacettepe University, Hospital, Department of Pediatric Neurology, Ankara, Turkey

6. Copenhagen University Hospital, The Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark

7. University Medical Centre, Groningen, Department of Pediatric Neurology, Groningen, The Netherlands

8. University San Raffaele, Neuroimaging Research Unit, Milan, Italy

9. The Children's Memorial Health Institute, Departments of Neurology and Epileptology, Warsaw, Poland

10. Erasmus MC, Department of Neurology, Rotterdam, The Netherlands

11. University of Vienna Medical School, Department of Neuropsychiatry of Childhood and Adolescence, Vienna, Austria

12. Evelina's Children's Hospital at Guys and St.Thomas' Hospitals, Department of Pediatric Neurology, London, UK

13. Karolinska Institute, Department of Neurology, Stockholm, Sweden

14. Institute of Neurology, Novi Sad, Republic of Serbia

15. Medical University Innsbruck, Division of Pediatric Neurology and Inherited Metabolic Disorders, Innsbruck, Austria

16. Bicêtre Hospital, Department of Neuropediatrics, University Paris Sud, France

17. Birmingham Children's Hospital, Department of Neurology, Birmingham, UK

18. Erasmus MC, Department of Neurology, Rotterdam, The Netherlands,

Abstract

About 3—5% of all patients with multiple sclerosis experience the onset of their disease under the age of 16. A significant proportion of paediatric multiple sclerosis patients develop significant cognitive disturbances and persistent physical disability. The high relapse rate and the morbidity in the paediatric multiple sclerosis population has triggered the use of disease-modifying therapies that have been shown to reduce relapse rate, disease progression and cognitive decline in adult patients with multiple sclerosis. Hard evidence for the right treatment and its appropriate timing is scarce in paediatric multiple sclerosis. Nevertheless, expertise in this field has grown thanks to recent open-label trials and experience generated in specialized centres. In spring 2009, a first meeting was held in Rotterdam with clinicians from 11 European countries (one from Canada) that are all active in the management of paediatric multiple sclerosis. One of the aims was to generate a common view on the management of paediatric multiple sclerosis patients. The result of this meeting is presented here to help standardize treatment and to support clinicians with less experience in this field.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

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