Evaluation of McDonald MRI criteria for dissemination in space in Korean patients with clinically isolated syndromes

Author:

Huh So-Young12,Kim Su-Hyun1,Kim Woojun13,Lee Sang-Hyun4,Park Min Su5,Ahn Suk-Won6,Kim Byung-Jo7,Cho Joong-Yang8,Kim Ho Jin1

Affiliation:

1. Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea

2. Department of Neurology, Kosin University College of Medicine, Korea

3. Current affiliation: Department of Neurology, The Catholic University of Korea, Korea

4. Department of Radiology, Research Institute and Hospital of National Cancer Center, Korea

5. Department of Neurology, College of Medicine, Yeungnam University College of Medicine, Korea

6. Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Korea

7. Department of Neurology, Korea University Medical Center, Korea

8. Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Korea

Abstract

We investigated the validity of the 2005 and 2010 McDonald magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) to predict the conversion of clinically definite multiple sclerosis (CDMS) in 94 Korean patients with clinically isolated syndromes (CIS). The sensitivity, specificity, accuracy, positive and negative predictive values of the 2005, 2010 McDonald DIS criteria were comparable to those observed in the Caucasian population. This finding suggests that after careful exclusion of alternative explanations, particularly neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD), both the 2005 and 2010 McDonald DIS criteria are also useful to predict conversion to CDMS in Korean patients with CIS.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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