Monocyte activation in multiple sclerosis-Reference-Cited by-同舟云学术

Monocyte activation in multiple sclerosis

Published:1998-06 Issue:3 Volume:4 Page:162-168
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Reder Anthony T¹,Genc Kursad¹,Byskosh Paul V¹,Porrini Anna Maria¹

Affiliation:

1. Department of Neurology, University of Chicago, MC2030 5841 South Maryland Avenue, Chicago, Illinois 60637, USA

Abstract

Monocytes, macrophages, and microglia have a central role in the CNS inflammation of MS. Monocytes are important in the earliest events in MS. Peripheral blood monocytes secrete prostaglandins before MS attacks. During clinical activity monocyte activation markers increase and IL-1 and TNF-a levels are elevated. Other monocyte products such as IL-10 reduce inflammation. IL-10 mRNA in MNC is increased during stable disease. Manipulation of monokine secretion and expression of monocyte surface proteins are reasonable approaches for immune therapy of MS.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/135245859800400314

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