Decentralised clinical trials in multiple sclerosis research

Author:

Garjani Afagh1ORCID,Liu Brandon Jun-Yu2,Allen Christopher Martin1ORCID,Gunzler Douglas David3,Gerry Stephen William4,Planchon Sarah Marie5ORCID,das Nair Roshan6ORCID,Chataway Jeremy7,Tallantyre Emma C8ORCID,Ontaneda Daniel5ORCID,Evangelou Nikos1ORCID

Affiliation:

1. Mental Health and Clinical Neurosciences Academic Unit, School of Medicine, University of Nottingham, Nottingham, UK/Academic Neurology, Nottingham University Hospitals NHS Trust, Nottingham, UK

2. School of Psychology, University of Nottingham, Nottingham, UK

3. The MetroHealth System and Case Western Reserve University, Cleveland, OH, USA

4. Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

5. Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA

6. Mental Health and Clinical Neurosciences Academic Unit, School of Medicine, University of Nottingham, Nottingham, UK/Institute of Mental Health, Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK

7. Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK/National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, UK/MRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK

8. Helen Durham Neuro-Inflammatory Unit, University Hospital of Wales, Cardiff, UK/Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK

Abstract

Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robustness of their designs and the efficiency of their conduct. Advances in digital and mobile technologies in recent years have facilitated this process and the first RCTs with decentralised elements became possible. Decentralised clinical trials (DCTs) are conducted remotely, enabling participation of a more heterogeneous population who can participate in research activities from different locations and at their convenience. DCTs also rely on digital and mobile technologies which allows for more flexible and frequent assessments. While hospitals quickly adapted to e-health and telehealth assessments during the COVID-19 pandemic, the conduct of conventional RCTs was profoundly disrupted. In this paper, we review the existing evidence and gaps in knowledge in the design and conduct of DCTs in MS.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3