Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy-Reference-Cited by-同舟云学术

Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy

Published:2013-07-18 Issue:4 Volume:20 Page:496-500
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Novakova L¹,Skoog B¹,Runmarker B¹,Ekholm S²,Winblad S³,Lisovskaja V⁴,Andersen O¹

Affiliation:

1. Section of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Sweden

2. Department of Imaging Sciences, University of Rochester, USA

3. Department of Psychology, University of Gothenburg, Sweden

4. Institute of Mathematical Statistics, Chalmers Technical University, and Institute of Mathematical Statistics, University of Gothenburg, Sweden

Abstract

The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the “CIS only” condition. The study was based on the longitudinally followed Gothenburg 1950–1964 incidence cohort ( n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained “CIS only”. Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining “CIS only”. Patients who had experienced no relapse during the first 25 years remained “CIS only” for the subsequent 25 years of follow-up.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458513496345

Reference12 articles.

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2. Predicting the Outcome of Optic Neuritis

3. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis

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