Low level of systemic autoimmunity in Western Australian multiple sclerosis patients-Reference-Cited by-同舟云学术

Low level of systemic autoimmunity in Western Australian multiple sclerosis patients

Published:2010-02-11 Issue:3 Volume:16 Page:351-354
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Wei Qiu ¹,Bundell Christine²,Wu Jing-Shan³,Castley Alison⁴,James Ian⁵,Hollingsworth Peter²,Christiansen Frank⁶,Carroll William M³,Mastaglia Frank L³,Kermode Allan G⁷

Affiliation:

1. Centre for Neuromuscular and Neurological disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Australia, Department of Neurology, the Third Affiliated Hospital of Sun yat-sen University, Guangzhou, China

2. Department of Clinical Immunology, PathWest, Queen Elizabeth Medical Centre, Perth, Australia

3. Centre for Neuromuscular and Neurological disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Australia

4. Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia

5. Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Australia

6. Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, Perth, Australia, School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia

7. Centre for Neuromuscular and Neurological disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Australia,

Abstract

Previous autoantibody (AAb) studies in multiple sclerosis MS have produced conflicting results. The objective of this study was to determine AAb frequency and association with the HLA-DRB1 genotype. Antinuclear antibody, antithyroid peroxidase and anti-aquaporin-4 assays and HLA-DRB1 genotyping were performed in 198 MS patients and 188 controls. There were no significant differences in AAb frequency or titres between MS and control subjects. AQP4-IgG was not found in any MS patients. There was no correlation between AAbs and HLA-DRB1 alleles. In conclusion, this study failed to confirm previous reports of increased AAbs in MS or to show an association between HLA-DRB1 genotype and the presence of AAbs.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458509355463

Reference10 articles.

1. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study

2. Autoimmune disease in families with multiple sclerosis: a population-based study

3. Autoimmunity in multiple sclerosis: study of a wide spectrum of autoantibodies

4. Antinuclear Antibodies in Multiple Sclerosis

5. Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients

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