The interaction between smoking and Epstein-Barr virus as multiple sclerosis risk factors may depend on age-Reference-Cited by-同舟云学术

The interaction between smoking and Epstein-Barr virus as multiple sclerosis risk factors may depend on age

Published:2013-10-09 Issue:6 Volume:20 Page:747-750
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Salzer Jonatan¹,Stenlund Hans²,Sundström Peter¹

Affiliation:

1. Department of Pharmacology and Clinical Neuroscience, Section of Neurology at Umeå University, Umeå, Sweden

2. Department of Public Health and Clinical Medicine, Umeå University, Sweden

Abstract

The multiple sclerosis (MS) risk factors smoking and remote Epstein-Barr virus (EBV) infection have been suggested to interact statistically, but the results are conflicting. In a prospective study on 192 MS cases and 384 matched controls, we analysed levels of cotinine as a marker of smoke exposure, and Epstein-Barr Nuclear Antigen-1 antibody reactivity. We assessed interaction on the additive and multiplicative scales, and estimated the effects of the risk factors across strata of each other. The results suggest that a negative interaction may be present in samples drawn at a young age, and a positive interaction among older subjects.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458513507820

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