Cerebellar volume loss in radiologically isolated syndrome

Author:

George Ilena C1,El Mendili Mohamed Mounir1,Inglese Matilde2,Azevedo Christina J3,Kantarci Orhun4,Lebrun Christine5,Siva Aksel6,Okuda Darin T7,Pelletier Daniel8

Affiliation:

1. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

2. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy/IRCCS Ospedale Policlinico San Martino, Genoa, Italy

3. Department of Neurology, University of Southern California, Los Angeles, CA, USA

4. Mayo Clinic, Rochester, MN, USA

5. Service de Neurologie, Hôpital Pasteur 2, Université Nice Côté d’Azur, Nice, France

6. Department of Neurology, Cerrahpasa School of Medicine, University of Istanbul, Istanbul, Turkey

7. UT Southwestern Medical Center, Dallas, TX, USA

8. Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Neuro-Immunology Division and USC Multiple Sclerosis Comprehensive Care Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Abstract

Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC ( p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

Funder

National Institutes of Health

race to erase ms

National Multiple Sclerosis Society

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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