Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis-Reference-Cited by-同舟云学术

Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis

Published:2010-08-25 Issue:12 Volume:16 Page:1513-1516
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Bartosik-Psujek Halina¹,Tabarkiewicz Jacek²,Pocinska Krystyna³,Stelmasiak Zbigniew³,Rolinski Jacek²

Affiliation:

1. Chair and Department of Neurology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland,

2. Chair and Department of Clinical Immunology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland

3. Chair and Department of Neurology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland

Abstract

In order to evaluate the effects of vitamin D3 on monocyte-derived dendritic cells (DCs) of relapsing—remitting multiple sclerosis patients, DCs differentiation and maturation were evaluated in vitro based on surface phenotypic changes. The expression of CD14, CD83, CD1a, CD80, CD86, CD206 and C209 was analysed by fluorescence-activated cell sorting. The results reveal that vitamin D3 inhibits both the differentiation and maturation of DCs. Moreover, inhibits the secretion of IL 23/12p40 and increases the secretion of CCL2. The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458510379611

Reference10 articles.

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4. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists

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