Leber’s hereditary optic neuropathy associated with a multiple-sclerosis-like picture in a man-Reference-Cited by-同舟云学术

Leber’s hereditary optic neuropathy associated with a multiple-sclerosis-like picture in a man

Published:2011-06 Issue:6 Volume:17 Page:763-766
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

La Russa Antonella¹,Cittadella Rita¹,Andreoli Virginia¹,Valentino Paola²,Trecroci Francesca¹,Caracciolo Manuela¹,Gallo Olivier¹,Gambardella Antonio¹²,Quattrone Aldo¹²

Affiliation:

1. Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy.

2. Institute of Neurology, University Magna Graecia, Catanzaro, Italy.

Abstract

A 35-year-old young man displayed Leber’s optic neuropathy (LHON) due to T14484C and multiple sclerosis (MS) phenotype that was dominated by symptoms and signs of spinal cord impairment. Magnetic resonance imaging (MRI) revealed demyelinating lesions extending from D6 to D11 in the spinal cord with gadolinium enhancement, while only three linear demyelinating lesions were seen on brain MRI. In the literature, a major involvement of the spinal cord was already reported in three of four male patients with the 14484 LHON mutation who developed MS, but the reasons of this peculiar association remain unknown, and further research in this area is needed.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458511404033

Reference10 articles.

1. Leber's Hereditary Optic Neuropathy

2. Leber hereditary optic neuropathy

3. Mitochondrial mutations of Leber's hereditary optic neuropathy: a risk factor for multiple sclerosis

4. Leber's hereditary optic neuropathy associated with multiple sclerosis: Harding's syndrome

5. Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy

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