Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis-Reference-Cited by-同舟云学术

Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

Published:2021-01-22 Issue:11 Volume:27 Page:1790-1793
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

de Mol CL¹^ORCID,Bruijstens AL²^ORCID,Jansen PR³,Dremmen MHG⁴,Wong YYM²,van der Lugt A⁵,White TJH⁶,Neuteboom RF²

Affiliation:

1. Department of Neurology, MS Center ErasMS, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

2. Department of Neurology, MS Center ErasMS, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

3. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands Department of Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands

4. The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

5. Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

6. Department of Child and Adolescent Psychiatry, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

Abstract

Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458521989220

Reference12 articles.

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1. A multicenter study of radiologically isolated syndrome in children and adolescents: Can we predict the course?;Multiple Sclerosis and Related Disorders;2023-11

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3. Radiologically Isolated Syndrome and the Multiple Sclerosis Prodrome in Pediatrics: Early Features of the Spectrum of Demyelination;Seminars in Pediatric Neurology;2023-07