Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis-Reference-Cited by-同舟云学术

Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

Published:2013-11-25 Issue:14 Volume:19 Page:1938-1942
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Fenoglio Chiara¹,Ridolfi Elisa¹,Cantoni Claudia¹²,De Riz Milena¹,Bonsi Rossana¹,Serpente Maria¹,Villa Chiara¹,Pietroboni Anna M¹,Naismith Robert T²,Alvarez Enrique²,Parks Becky J²,Bresolin Nereo¹,Cross Anne H²,Piccio Laura M²,Galimberti Daniela¹,Scarpini Elio¹

Affiliation:

1. Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy

2. Department of Neurology, Washington University School of Medicine, USA

Abstract

Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients ( p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS ( p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458513485654

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