Choroid plexus volume differentiates MS from its mimics

Author:

Levit Elle12,Ren Zheng3ORCID,Gonzenbach Virgilio3,Azevedo Christina J4ORCID,Calabresi Peter A5ORCID,Cree Bruce AC6ORCID,Freeman Leorah7,Longbrake Erin E8,Oh Jiwon9,Schindler Matthew K10,Sicotte Nancy L11,Reich Daniel S12ORCID,Ontaneda Daniel13ORCID,Sati Pascal11ORCID,Cao Quy3ORCID,Shinohara Russell T3,Solomon Andrew J12ORCID

Affiliation:

1. Department of Neurological Sciences, Larner College of Medicine, The University of Vermont, Burlington, VT, USA

2. The University of Vermont Medical Center, Burlington, VT, USA

3. Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics and Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

4. Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

5. Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

6. UCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

7. Dell Medical School, The University of Texas at Austin, Austin, TX, USA

8. Department of Neurology, Yale University, New Haven, CT, USA

9. Division of Neurology, Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

10. Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

11. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

12. Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

13. Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA

Abstract

This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 with alternative diagnoses were included. CPV was automatically segmented from 3T magnetic resonance imaging (MRI), followed by manual review to remove misclassified tissue. Mean normalized choroid plexus volume (nCPV) to intracranial volume demonstrated relatively high specificity for MS participants in each cohort (0.80 and 0.76) with an area under the receiver-operator characteristic curve of 0.71 (95% confidence interval (CI) = 0.55–0.87) and 0.65 (95% CI = 0.52–0.77). In this preliminary study, nCPV differentiated MS from its mimics.

Funder

Race to Erase MS

Common Fund

Intramural Research Program of National Institute of Neurological Disorders and Stroke

Publisher

SAGE Publications

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