Aging and multiple sclerosis-Reference-Cited by-同舟云学术

Aging and multiple sclerosis

Published:2016-02-19 Issue:6 Volume:22 Page:717-725
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Sanai Shaik Ahmed¹,Saini Vasu²,Benedict Ralph HB²,Zivadinov Robert²,Teter Barbara E³,Ramanathan Murali²,Weinstock-Guttman Bianca²

Affiliation:

1. Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, The State University of New York, Buffalo, NY, USA

2. Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, The State University of New York, Buffalo, NY, USA/New York State MS Consortium, University at Buffalo, The State University of New York, Buffalo, NY, USA/Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA

3. Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, The State University of New York, Buffalo, NY, USA/New York State MS Consortium, University at Buffalo, The State University of New York, Buffalo, NY, USA/Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA

Abstract

The life expectancy and average age of persons with multiple sclerosis (MS) have increased significantly during the last two decades. The introduction of disease-modifying therapies and a better delineation and understanding of the superimposed comorbidities often diagnosed in MS patients are probably the most important factors accountable for the increase in aging MS population worldwide. Healthcare teams must therefore address the problems arising due to advancing age superimposed on this chronic neurologic disease. In this review, we focus on the physiology of aging, its effects on MS disease course, and the pathological and immunological changes associated with aging and disease progression. Additionally, we discuss the common comorbidities that occur in aging persons with MS that may arise either as a result of the aging process or from relentless chronic MS disease progression as well as the challenges on differentiating the two processes for a more appropriate therapeutic approach.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458516634871

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