Pulmonary paracoccidioidomycosis associated with the use of natalizumab in multiple sclerosis

Author:

Almeida Kelson James1ORCID,Barreto-Soares Raissa Viera2,Campos-Sousa Raimundo Nonato3,Campos-Sousa Maria Graças3,Bor-Seng-Shu Edson4

Affiliation:

1. Department of Neurology, Central Institute, Clínicas Hospital, University of São Paulo, São Paulo, Brazil

2. Facid Devry Faculty of Medicine, Teresina, Brazil

3. Department of Neurology, Federal University of Piauí, Teresina, Brazil

4. Division of Neurosurgery, Department of Neurology, University of São Paulo, São Paulo, Brazil

Abstract

Background: Natalizumab (NTZ) is a monoclonal antibody with an immunosuppressive effect that reduces the inflammation of the central nervous system, and it has been used for the treatment of relapsing-remitting multiple sclerosis (RRMS). In patients with low cellular immune response, systemic mycosis arising from endemic areas may occur. Results and Conclusion: In this article, we will describe a case of paracoccidioidomycosis as a complication to treatment with NTZ in an RRMS patient.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

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