Cognitive impairment in pediatric-onset multiple sclerosis is detected by the Brief International Cognitive Assessment for Multiple Sclerosis and computerized cognitive testing

Author:

Charvet Leigh E1,Shaw Michael1,Frontario Ariana2,Langdon Dawn3,Krupp Lauren B1

Affiliation:

1. Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU Langone Medical Center, School of Medicine, New York University, New York, NY, USA

2. Lake Erie College of Osteopathic Medicine, Pennsylvania, PA, USA

3. Royal Holloway, University of London, Egham, UK

Abstract

Background: Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible. Objectives: The goal of this study was to measure the sensitivity of two cognitive assessment approaches that are brief, repeatable, and suitable for clinical practice and for multicenter investigation. Methods: Participants with POMS ( n = 69) were consecutively evaluated as part of outpatient neurologic visits and compared to healthy control participants (HC, n = 66) using the Brief International Cognitive Assessment for MS (BICAMS) approach and timed information processing measures from Cogstate, a computer-based assessment. Results: There was strong agreement in the detection rate of impairment between both assessments, with 26% for the BICAMS and 27% for Cogstate. Two of the Cogstate tasks were the most sensitive individual measures. Conclusion: Both the BICAMS and Cogstate timed processing measures offer practical, sensitive, and standardized approaches for cognitive screening assessment in POMS.

Funder

National Multiple Sclerosis Society

National Institutes of Health

The Lourie Foundation, Inc

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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