Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies-Reference-Cited by-同舟云学术

Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies

Published:2020-02-27 Issue:2 Volume:27 Page:303-308
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Sechi Elia¹,Krecke Karl N²,Pittock Sean J³,Dubey Divyanshu³,Lopez-Chiriboga A Sebastian⁴^ORCID,Kunchok Amy¹,Weinshenker Brian G¹,Zalewski Nicholas L¹,Flanagan Eoin P³^ORCID

Affiliation:

1. Department of Neurology, Mayo Clinic, Rochester, MN, USA

2. Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN, USA

3. Department of Neurology, Mayo Clinic, Rochester, MN, USA/Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

4. Department of Neurology, Mayo Clinic, Jacksonville, FL, USA

Abstract

Background: Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty. Objective and Methods: We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019). Results: The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients. Conclusions: A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.

Funder

national institute of neurological disorders and stroke

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458520907900

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