Impact of COVID-19 vaccination or infection on disease activity in a radiologically isolated syndrome cohort: The VaxiRIS study-Reference-Cited by-同舟云学术

Impact of COVID-19 vaccination or infection on disease activity in a radiologically isolated syndrome cohort: The VaxiRIS study

Published:2023-06-15 Issue:9 Volume:29 Page:1099-1106
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Cohen Mikael¹^ORCID,Thomel-Rocchi Océane²,Siva Aksel³^ORCID,Okuda Darin T⁴^ORCID,Karabudak Rana⁵,Efendi Hüsnü⁶,Terzi Murat⁷,Carra-Dalliere Clarisse⁸^ORCID,Durand-Dubief Francoise⁹,Thouvenot Eric¹⁰^ORCID,Ciron Jonathan¹¹^ORCID,Zephir Helene¹²,Bourre Bertrand¹³,Casez Olivier¹⁴,De Seze Jérôme¹⁵,Moreau Thibault¹⁶,Neau Jean-Philippe¹⁷,Pelletier Daniel¹⁸,Kantarci Orhun¹⁹,Tutuncu Melih³,Derache Nathalie²⁰,Bensa Caroline²¹,Louapre Celine²²,Benoit Jeanne¹,Landes-Chateau Cassandre¹,Lebrun-Frenay Christine¹^ORCID

Affiliation:

1. Department of Neurology, CRC-SEP, CHU de Nice, Pasteur 2 Hospital, Nice, France UR2CA-URRIS, Côte d’Azur University, Nice, France

2. Department of Neurology, CRC-SEP, CHU de Nice, Pasteur 2 Hospital, Nice, France

3. Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey

4. The University of Texas Southwestern Medical Center, Dallas, TX, USA

5. School of Medicine, Hacettepe University, Ankara, Turkey

6. School of Medicine, Kocaeli University, Kocaeli, Turkey

7. School of Medicine, Ondokuz Mayis University, Samsun, Turkey

8. Department of Neurology, CRC-SEP, CHU de Montpellier, Gui de Chauliac Hospital, Montpellier, France

9. Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France

10. Institut de Génomique Fonctionnelle, Université de Montpellier, Centre National de Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Montpellier, France

11. Department of Neurology, Centre de Ressource et Competence Sclérose En Plaques, Centre Hospitalier Universitaire de Toulouse, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche1291, Centre National de Recherche Scientifique Unité Mixte de Recherche 5051, Université Toulouse III, Toulouse, France

12. Université de Lille, Inserm Unité Mixte de Recherche-S 1172 LilNcog, Centre Hospitalier Universitaire Lille, Fédération Hospitalo-Universitaire Precise, Lille, France

13. Department of Neurology, CHU Rouen, Rouen, France

14. Pathologies Inflammatoires du Système Nerveux, Neurologie, CHU Grenoble Alpes, T-RAIG (Translational Research in Autoimmunity and Inflammation Group) TIMC-IMAG, Université de Grenoble-Alpes, CHU Grenoble-Alpes, Grenoble, France

15. Department Clinical Investigation Center, Department of Neurology, Centre Hospitalier Universitaire de Strasbourg, Institut National de la Santé et de la Recherche Médicale, Strasbourg, France

16. Department of Neurology, Centre Hospitalier Universitaire de Dijon, Dijon, France

17. Department of Neurology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France

18. University of Southern California, Los Angeles, CA, USA

19. Mayo Clinic, Rochester, MN, USA

20. Department of Neurology, Centre Hospitalier Universitaire de Caen Normandie, Caen, France

21. Neurology Department, CRC-SEP, Hopital Fondation Adolphe de Rothschild, Paris, France

22. CIC Neurosciences, Department of Neurology, Sorbonne University, Assistance Publique des Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France

Abstract

Background: Vaccination in patients with multiple sclerosis (MS) treated with immunosuppressive drugs is highly recommended. Regarding COVID-19 vaccination, no specific concern has been raised. Objectives: We aimed to evaluate if COVID-19 vaccination or infection increased the risk of disease activity, either radiological or clinical, with conversion to MS in a cohort of people with a radiologically isolated syndrome (RIS). Methods: This multicentric observational study analyzed patients in the RIS Consortium cohort during the pandemic between January 2020 and December 2022. We compared the occurrence of disease activity in patients according to their vaccination status. The same analysis was conducted by comparing patients’ history of COVID-19 infection. Results: No difference was found concerning clinical conversion to MS in the vaccinated versus unvaccinated group (6.7% vs 8.5%, p > 0.9). The rate of disease activity was not statistically different (13.6% and 7.4%, respectively, p = 0.54). The clinical conversion rate to MS was not significantly different in patients with a documented COVID-19 infection versus non-infected patients. Conclusion: Our study suggests that COVID-19 infection or immunization in RIS individuals does not increase the risk of disease activity. Our results support that COVID-19 vaccination can be safely proposed and repeated for these subjects.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/13524585231179669

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