Subtypes and location of (juxta)cortical lesions relate to cognitive dysfunction in people with multiple sclerosis-Reference-Cited by-同舟云学术

Subtypes and location of (juxta)cortical lesions relate to cognitive dysfunction in people with multiple sclerosis

Published:2024-06-13 Issue: Volume: Page:
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Krijnen Eva A¹²^ORCID,Kouwenhoven Rose-Marie¹,Noteboom Samantha¹^ORCID,Barkhof Frederik³⁴^ORCID,Uitdehaag Bernard MJ⁵,Klawiter Eric C²,Steenwijk Martijn D¹,Schoonheim Menno M¹^ORCID,Koubiyr Ismail¹

Affiliation:

1. MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands

2. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

3. MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands

4. Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK

5. MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands

Abstract

Background: Cortical lesion subtypes’ occurrence and distribution across networks may shed light on cognitive impairment (CI) in multiple sclerosis (MS). Methods: In 332 people with MS, lesions were classified as intracortical, leukocortical or juxtacortical based on artificially generated double inversion-recovery images. Results: CI-related leukocortical lesion count increases were greatest within sensorimotor and cognitive networks ( p < 0.001). Only intracortical lesion count could distinguish between cognitive groups ( p = 0.024). Effect sizes were two- to four-fold larger than differences between MS phenotypes. Conclusion: In CI-MS, leukocortical lesions predominate, whereas intracortical lesions distinguish cognitive groups. Lesions’ grey matter (GM) involvement might be decisive for cognition in MS, surpassing overall disease burden.

Funder

ZonMw

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/13524585241260968

Reference10 articles.

1. Cognition in multiple sclerosis

2. Cortical lesions at diagnosis predict long‐term cognitive impairment in multiple sclerosis: A 20‐year study

3. Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis

4. Inflammatory Cortical Demyelination in Early Multiple Sclerosis

5. Intracortical lesions by 3T magnetic resonance imaging and correlation with cognitive impairment in multiple sclerosis