Anti-adipogenic Activity of Cordyceps militaris in 3T3-L1 Cells-Reference-Cited by-同舟云学术

Anti-adipogenic Activity of Cordyceps militaris in 3T3-L1 Cells

Published:2011-12 Issue:12 Volume:6 Page:1934578X1100601
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Liu Qing¹,Hong In Pyo²,Ahn Mi-Jeong³,Yoo Hwan-Soo¹,Han Sang-Bae¹,Hwang Bang Yeon¹,Lee Mi Kyeong¹

Affiliation:

1. College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea

2. National Academy of Agricultural Science, Suwon, Gyunggi 441-707, Korea

3. College of Pharmacy, Gyeongsang National University, Jinju 660-751, Korea

Abstract

Inhibition of adipocytes differentiation is suggested to be an important strategy for prevention and/or treatment of obesity. In our present study, Cordyceps militaris showed significant inhibitory activity on adipocyte differentiation in 3T3-L1 preadipocytes as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led to the isolation of cordycepin (1), guanosine (2) and tryptophan (3) as active compounds. All the three compounds were more effective in the prevention of early stage of adipogenesis than in lipolysis. In addition, combinational treatment of three compounds significantly increased anti-adipogenic activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1100601213

Reference14 articles.

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2. Adipocytes as regulators of energy balance and glucose homeostasis

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4. Phytochemicals and regulation of the adipocyte life cycle☆

5. Antifatigue and Antistress Effect of the Hot-Water Fraction from Mycelia of Cordyceps sinensis

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