A Polar Cannabinoid from Cannabis Sativa Var. Carma-Reference-Cited by-同舟云学术

A Polar Cannabinoid from Cannabis Sativa Var. Carma

Published:2008-12 Issue:12 Volume:3 Page:1934578X0800301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Appendino Giovanni¹,Giana Anna¹,Gibbons Simon²,Maffei Massimo³,Gnavi Giorgio³,Grassi Gianpaolo⁴,Sterner Olov⁵

Affiliation:

1. Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Via Bovio 6, 28100 Novara, Italy

2. Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, UK

3. Dipartimento di Biologia Vegetale e Centro di Eccellenza CEBIOVEM, Università di Torino, Viale Mattioli 25, 10125 Torino, Italy

4. CRA-CIN Centro di Ricerca per le Colture Industriali, Sede Distaccata di Rovigo, Via Amendola 82, 45100 Rovigo, Italy

5. Department of Organic Chemistry, Lund University, P.O. Box 124, 221 00 Lund, Sweden

Abstract

The aerial parts of Cannabis sativa var. Carma afforded a novel polar cannabinoid whose structure was established as rac-6′,7′-dihydro,6′,7′-dihydroxycannabigerol (carmagerol, 1) on the basis of spectroscopic data and semisynthesis from cannabigerol (2a). The dihydroxylation of the ω-double bond was detrimental to the anti-bacterial activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0800301207

Reference10 articles.

1. Managing neuropathic pain with Sativex®: a review of its pros and cons

2. Chemical constituents of marijuana: The complex mixture of natural cannabinoids

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5. A Regiodivergent Synthesis of Ring A C-Prenylflavones

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